Surfactant replacement therapy in acute respiratory distress syndrome from viral pneumonia
- PMID: 8814477
- PMCID: PMC7095348
- DOI: 10.1007/BF01708102
Surfactant replacement therapy in acute respiratory distress syndrome from viral pneumonia
Abstract
A modified natural surfactant was administered to a patient with life-threatening adult respiratory distress syndrome caused by viral pneumonia. Subsequently, there was a marked improvement in gas exchange. In order to assess the mechanism for improved oxygenation, computed tomography of the lungs was done. Quantitative analysis of the scans taken before and after surfactant administration indicates that improvement in gas exchange was largely due to the expansion of underinflated and collapsed lung areas. Although this is a single case report, it provides insight into the possible beneficial effect of instilled surfactant in severe respiratory distress from viral pneumonia.
References
-
- Spragg RG, Gilliard N, Richman P, Smith RM, Hite RD, Pappert D, Robertson B, Curstedt T, Strayer D. Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome. Chest. 1994;105:195–202. - PubMed
-
- Weg JG, Balk RA, Tharratt RS, Jenkinson SG, Shah JB, Zaccardelli D, Horton J, Pattishall EN. Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. JAMA. 1994;272:1433–1438. - PubMed
-
- Baum M, Benzer H, Putensen Ch, Koller W, Putz G. Biphasic positive airway pressure (BIPAP): a new form of assisted ventilation. Anaesthesist. 1989;38:452–458. - PubMed
-
- Lachmann B, Gommers D. Is it rational to treat pneumonia with exogenous surfactant? Eur Respir J. 1993;6:1427–1428. - PubMed
-
- Goldsmith LS, Greenspan JS, Rubenstein SD, Wolfson MR, Shaffer TH. Immediate improvement in lung volume after exogenous surfactant: alveolar recruitment versus increased distention. J Pediatr. 1991;119:424–428. - PubMed
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