Cytogenetic findings in renal cell carcinoma

Abstract

Cytogenetic characterization of 24 renal cell carcinomas (RCCs) was performed. The various RCC subtypes included 8 chromophobe RCCs, 12 nonpapillary RCCs, and 4 papillary RCCs. Loss of chromosomes 1, 2, 6, 10, and 17 were observed in 5 of 8 chromophobe RCCs. Five of the 12 nonpapillary RCCs showed abnormalities involving chromosome 3. These were deletion of the 3p13 region, loss of the whole chromosome 3, and unbalanced translocation resulting in a derivative. Of the 4 papillary RCCs, two showed trisomy 7 and 17 along with other abnormalities, one had trisomy for chromosomes 7, 12, and 13, along with loss of chromosome #5 and Y chromosomes, and another papillary RCC revealed trisomy 15 and trisomy 17. These results further show that specific cytogenetic abnormalities are associated with various subtypes of RCCs.