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Review
. 1996 Jul;9(1):60-5; discussion 66-7.
doi: 10.2165/00002512-199609010-00006.

Galanthamine

B Fulton  1 , P Benfield
Affiliations
Review

Galanthamine

B Fulton et al. Drugs Aging. 1996 Jul.

Abstract

Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue. Galanthamine attenuates drug-and lesion-induced cognitive deficits in animal models of learning and memory. Preliminary results in patients with Alzheimer's disease have reported galanthamine to be associated with a reduction in cognitive deterioration on some neuropsychiatric rating scales. Nausea and vomiting are the most commonly reported adverse effects; liver toxicity has not been reported to date.

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