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. 1996 Jul;5(7):1421-5.
doi: 10.1002/pro.5560050720.

The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues

P Bork  1 , N P Brown, H Hegyi, J Schultz
Affiliations

The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues

P Bork et al. Protein Sci. 1996 Jul.

Abstract

A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

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