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. 1995:46:131-7.

The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue

J Kornhuber  1 , B Herr, J Thome, P Riederer
Affiliations
  • PMID: 8821048

The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue

J Kornhuber et al. J Neural Transm Suppl. 1995.

Abstract

We have estimated the affinity of the antiparkinsonian drug budipine to the PCP binding site of the NMDA receptor and to sigma 1 binding sites in membranes from postmortem human brain frontal cortex. The affinity of budipine to both binding sites is in a concentration range that may be reached under therapeutic conditions (Ki-values of about 12 and 2 microM at the PCP and sigma 1 binding site, respectively). Interactions with NMDA receptors as well as sigma 1 binding sites may contribute to the antiparkinsonian effects of budipine.

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