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. 1977 May;298(1):57-9.
doi: 10.1007/BF00510987.

The reversibility of the inhibition of intestinal amino-acid transport by harmaline

M Buclon, F V Sepúlveda, J W Robinson

The reversibility of the inhibition of intestinal amino-acid transport by harmaline

M Buclon et al. Naunyn Schmiedebergs Arch Pharmacol. 1977 May.

Abstract

The inhibitory aciton of harmaline on L-phenylalanine uptake by guinea-pig intestinal rings is fully reversible provided only low concentrations of the inhibitor are used; if the concentration is raised to a sufficient extent to enable the drug to interfere with sodium pumping or cellular metabolic reactions, as witnessed by its effect on tissue oxygen consumption, then the inhibition of L-phenylalanine uptake is only reversible if short contact times are employed.

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