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Review
. 1996;38(1):3-9.
doi: 10.1007/BF01803778.

Recombinant immunotoxins

I Pastan  1 , L H Pai, U Brinkmann, D FitzGerald
Affiliations
Review

Recombinant immunotoxins

I Pastan et al. Breast Cancer Res Treat. 1996.

Abstract

Pseudomonas exotoxin has been genetically modified so that it targets cancer cells. This was accomplished by deleting its cell binding domain and replacing it with Fv fragments of antibodies that react with breast, colon, and other cancers. Several recombinant immunotoxins are now in clinical trials.

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