Immunomodulative effects of aflatoxins and selenium on human peripheral blood lymphocytes
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- PMID: 8829345
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Immunomodulative effects of aflatoxins and selenium on human peripheral blood lymphocytes
Vet Hum Toxicol.
1996 Aug.
Abstract
We investigated the antagonist immunomodulative properties of aflatoxin B1 and selenium on human peripheral blood lymphocytes by 2 colorimetric in vitro cytotoxicity assays, the neutral red uptake and the thiazolyl blue tetrazolium bromide assay. Immunotoxic properties of these substances were determined by a (3H)-thymidine DNA incorporation assay on phytohemagglutinin (PHA) stimulated and non-stimulated lymphocytes. Aflatoxin B1 and selenium, when studied separately, had an immunosuppressive effect on PHA stimulated and non-stimulated human peripheral blood lymphocytes. When they were studied together, they had an antagonistic effect on this immunological parameter.
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