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. 1996 Aug;38(4):274-7.

Immunomodulative effects of aflatoxins and selenium on human peripheral blood lymphocytes

G Methenitou  1 , C Maravelias, L Koutsogeorgopoulou, S Athanaselis, A Koutselinis
Affiliations
  • PMID: 8829345

Immunomodulative effects of aflatoxins and selenium on human peripheral blood lymphocytes

G Methenitou et al. Vet Hum Toxicol. 1996 Aug.

Abstract

We investigated the antagonist immunomodulative properties of aflatoxin B1 and selenium on human peripheral blood lymphocytes by 2 colorimetric in vitro cytotoxicity assays, the neutral red uptake and the thiazolyl blue tetrazolium bromide assay. Immunotoxic properties of these substances were determined by a (3H)-thymidine DNA incorporation assay on phytohemagglutinin (PHA) stimulated and non-stimulated lymphocytes. Aflatoxin B1 and selenium, when studied separately, had an immunosuppressive effect on PHA stimulated and non-stimulated human peripheral blood lymphocytes. When they were studied together, they had an antagonistic effect on this immunological parameter.

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