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. 1995 Sep;36(3):551-5.
doi: 10.1093/jac/36.3.551.

Efficacy of quinolones in preventing Staphylococcus aureus-induced abscess in mice

M A Cohen  1 , J W Gage, M D Huband, M A Meservey, S R VanderRoest, S L Yoder
Affiliations

Efficacy of quinolones in preventing Staphylococcus aureus-induced abscess in mice

M A Cohen et al. J Antimicrob Chemother. 1995 Sep.

Abstract

The new fluoroquinolones clinafloxacin, CI-990 (PD 131112/PD 131628), sparfloxacin, and PD 138312 were bactericidal against Staphylococcus aureus with MICs > or = 4-fold lower than ciprofloxacin values. In a murine subcutaneous abscess model (subcutaneous/oral dosing) the new drugs displayed protective activities against five strains which were generally higher (up to 19-fold) than ciprofloxacin values.

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