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Comparative Study
. 1996 Oct 7;394(3):325-9.
doi: 10.1016/0014-5793(96)00901-5.

A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain

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Free article
Comparative Study

A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain

B F O'Dowd et al. FEBS Lett. .
Free article

Abstract

Following the cloning of the dopamine receptors we continued a search of the human genome for related genes. We searched an EST data base and discovered cDNA fragments encoding novel G protein-coupled receptor genes. The available GenBank sequence of one of these EST fragments showed that it encoded a receptor with closest similarity to the D2 dopamine and adrenergic receptors. This cDNA was used to isolate the gene (GPR19), and the encoded receptor also demonstrated similarity with the neuropeptide Y receptor. The gene was mapped to chromosome 12, in region p13.2-12.3. Northern blot analysis revealed expression of GPR19 in peripheral regions, and brain regions significantly overlapping with the D2 receptor gene expression. A sequence of the rat orthologue of GPR19 was obtained and in situ hybridization analysis demonstrated a very abundant expression in rat brain.

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