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. 1996 Jul;155(7):608-11.
doi: 10.1007/BF01957914.

Bronchial constriction after nebulized tobramycin preparations and saline in patients with cystic fibrosis

W H Nikolaizik  1 , V Jenni-Galović, M H Schöni
Affiliations

Bronchial constriction after nebulized tobramycin preparations and saline in patients with cystic fibrosis

W H Nikolaizik et al. Eur J Pediatr. 1996 Jul.

Abstract

To assess the airway response to inhaled tobramycin we measured flow volume curves in 12 patients with cystic fibrosis. Immediately and/or 2 min after tobramycin inhalations there was a significant fall in lung function regardless of the concentration used; isotonic saline caused similar obstruction but not a complete cessation of peripheral airflows. The baseline oxygen saturation was significantly correlated with the fall in lung function. Ten minutes after inhalation lung function tests returned to baseline values.

Conclusion: As salbutamol could significantly reduce airway obstruction tobramycin should always be inhaled in combination with a bronchodilator.

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