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Review
. 1996 Jan;74(1):35-42.
doi: 10.1007/BF00202070.

Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors

H Friess  1 , P Berberat, M Schilling, J Kunz, M Korc, M W Büchler
Affiliations
Review

Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors

H Friess et al. J Mol Med (Berl). 1996 Jan.

Abstract

Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGF beta receptor I-III), growth factors (EGF, TGF alpha, TGF beta-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.

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References

    1. Cancer Res. 1993 Jun 1;53(11):2472-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7567-70 - PubMed
    1. Genes Chromosomes Cancer. 1992 Jan;4(1):1-15 - PubMed
    1. Biochem Biophys Res Commun. 1990 Dec 31;173(3):1239-47 - PubMed
    1. Lancet. 1990 Mar 24;335(8691):675-9 - PubMed

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