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Comparative Study
. 1996 Feb;40(2):477-80.
doi: 10.1128/AAC.40.2.477.

Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori

J Versalovic  1 , D Shortridge, K Kibler, M V Griffy, J Beyer, R K Flamm, S K Tanaka, D Y Graham, M F Go
Affiliations
Comparative Study

Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori

J Versalovic et al. Antimicrob Agents Chemother. 1996 Feb.

Abstract

Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin-susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens.

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