Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Feb;23(1):67-70.
doi: 10.1111/j.1744-313x.1996.tb00265.x.

Association of MHC class I with spondyloarthropathies in Kuwait

S A Alharbi  1 , F F Mahmoud, A Al Awadi, R A Al Jumma, F Khodakhast, S M Alsulaiman
Affiliations

Association of MHC class I with spondyloarthropathies in Kuwait

S A Alharbi et al. Eur J Immunogenet. 1996 Feb.

Abstract

This study is the first to assess the prevalence of HLA B27 in Kuwaiti patients with ankylosing spondylitis (AS) or related spondyloarthropathies compared to healthy controls. Positive HLA B27 was found in nine (25.7%) of 35 patients, but only in 22 (4%) of 544 controls (P = 0.000). A significant difference in Cw2 and Cw6 between patients and controls was also found (P < 0.01 and 0.000, respectively), suggesting a linkage disequilibrium between B27 and Cw2 (P < 0.000) in the Kuwaiti population. These findings suggest that B27-positive Kuwaitis are at high risk of developing AS and spondyloarthropathies, especially if they carry Cw2 and Cw6: The importance of HLA Cw loci is becoming increasingly apparent in disease association studies.

PubMed Disclaimer

Publication types