Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jul 1;725(2):276-80.
doi: 10.1016/0006-8993(96)00406-4.

Fucose and fucosyllactose enhance in-vitro hippocampal long-term potentiation

H Matthies  1 , S Staak, M Krug
Affiliations

Fucose and fucosyllactose enhance in-vitro hippocampal long-term potentiation

H Matthies et al. Brain Res. .

Abstract

Bath application of L-fucose and 2-fucosyllactose (2FI) increases the potentiation of the population spike amplitude (POP-spike) and the field excitatory postsynaptic potential (fEPSP) after tetanization of the Schaffer collaterals of the rat hippocampus. The ineffective isomers D-fucose and 3-fucosyllactose (3-FI) have no such effect. Since not only the maintenance of long-term potentiation LTP is influenced but also its induction is drastically improved, an effect of the sugars via the formation of glycoproteins but also via different actions on induction mechanisms is discussed.

PubMed Disclaimer

LinkOut - more resources