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. 1977 Jul;12(1):11-5.
doi: 10.1128/AAC.12.1.11.

Human interferon: mass production in a newly established cell line, MG-63

A Billiau, V G Edy, H Heremans, J Van Damme, J Desmyter, J A Georgiades, P De Somer

Human interferon: mass production in a newly established cell line, MG-63

A Billiau et al. Antimicrob Agents Chemother. 1977 Jul.

Abstract

MG-63 cells, a line derived from an osteosarcoma, produced high yields of interferon after superinduction with polyinosinic acid.polycytidylic acid, cycloheximide, and actinomycin D. Advantages of MG-63 cells over diploid fibroblasts as a substrate are: no requirement for aging between confluency and induction, no requirement for priming, and 3.7-fold higher yields per square centimeter of culture surface. Physicochemically and biologically, MG-63 cell interferon resembles fibroblast rather than leukocyte interferon.

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