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. 1977 Jul;12(1):26-30.
doi: 10.1128/AAC.12.1.26.

2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid

A Martel, N Moreau, M L Capmau, C J Soussy, J Duval

2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid

A Martel et al. Antimicrob Agents Chemother. 1977 Jul.

Abstract

A wild-type strain of Staphylococcus aureus that inactivates the 4,6-glycosidically linked deoxystreptamine aminoglycoside antibiotics by a plasmid-mediated process was found to harbor two enzymes: an acetyltransferase of the AAC(6') type and a new phosphotranferase specific to the gentamicin components. The target of this last enzyme is the 2''-hydroxyl function of these antibiotics, since one inactivated compound is 2''-(O)-phosphorylsisomicin.

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References

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