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Comparative Study
. 1996 Mar 15;32(3):328-33.
doi: 10.1006/geno.1996.0126.

Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human

J A Tischfield  1 , Y R Xia, D M Shih, I Klisak, J Chen, S J Engle, A N Siakotos, M V Winstead, J J Seilhamer, V Allamand, G Gyapay, A J Lusis
Affiliations
Comparative Study

Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human

J A Tischfield et al. Genomics. .

Abstract

The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34-p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.

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