Temporal distribution of rotavirus G-serotypes in the West Midlands region of the United Kingdom, 1983-1994

Abstract

Samples of rotavirus from cases of acute gastroenteritis, occurring in the West Midlands region of the United Kingdom during the winter months of 1983 to 1994, were tested by enzyme-immunoassay for G-serotype (VP7). Statistically significant changes in the relative prevalence of serotypes occurred each year (p-values in chi-square tests were: p < 0.05 or p < 0.01). No consistent pattern was associated with these changes. G1, G2, G3, and G4 were the most common serotypes detected throughout the study period, accounting for 93.2%. Serotypes G5, G8, and G10 were detected in 0.4% samples, and serotypes other than G1 to G4 were detected in 6.8% samples. Thus, the rotavirus serotypes are less diverse here compared to other locations. These data are important for the development of an appropriate rotavirus vaccine.