Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jan-Mar;21(1):23-6.
doi: 10.1007/BF03190274.

Lipid peroxidation: the role of Ca2+ and protection by calcinine

R S Pereira  1
Affiliations

Lipid peroxidation: the role of Ca2+ and protection by calcinine

R S Pereira. Eur J Drug Metab Pharmacokinet. 1996 Jan-Mar.

Abstract

When calcinine (A-23187) (2 microM), a known Ca2+ ionophore, is present, a significant protection is observed to a mitochondrial suspension undergoing lipid peroxidation by Fe(2+)-citrate complex. A-23187 can remove Ca2+, which seems to have an important role in the lipid peroxidation process, from its 'lesive sites' and consequently preventing the damage. This information has importance in terms of knowing the mechanisms and avoiding the damages of lipid peroxidation that occur in some pathological cases such as tumor promotion and hemochromatosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biochem Pharmacol. 1992 Nov 3;44(9):1795-801 - PubMed
    1. J Biol Chem. 1990 Nov 15;265(32):19955-60 - PubMed
    1. Chem Biol Interact. 1977 Dec;19(3):383-6 - PubMed
    1. Science. 1985 Jan 25;227(4685):375-81 - PubMed
    1. Cancer Commun. 1989;1(5):329-34 - PubMed

LinkOut - more resources