Prolonged ciprofloxacin administration does not accelerate neutrophil recovery after autologous bone marrow transplantation

Abstract

Study objective: To determine whether prolonged ciprofloxacin administration following autologous bone marrow transplantation (ABMT) accelerates neutrophil recovery.

Design: Retrospective analysis of 40 consecutive patients undergoing ABMT.

Setting: Tertiary care bone marrow transplant program.

Patients: Two sequential arms of 20 consecutive patients with Hodgkin's disease or non-Hodgkin's lymphoma undergoing ABMT.

Interventions: The first arm received ciprofloxacin from the day of transplantation until initiation of broad-spectrum antibiotic therapy (median 5 days) while the second arm continued ciprofloxacin until recovery of the neutrophil count (median 15 days).

Measurements and main results: Neutrophil recovery was similar in the two groups (16 vs 14 days; p = 0.41). There were no differences in platelet recovery, bacteremia, or treatment-related mortality.

Conclusion: Prolonged ciprofloxacin administration does not significantly accelerate neutrophil recovery following ABMT.