Comparative Study
doi: 10.1002/(SICI)1097-0061(199607)12:9%3C893::AID-YEA973%3E3.0.CO;2-I.
A Candida albicans gene encoding a DNA ligase
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- PMID: 8840507
- DOI: 10.1002/(SICI)1097-0061(199607)12:9%3C893::AID-YEA973%3E3.0.CO;2-I
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Comparative Study
A Candida albicans gene encoding a DNA ligase
Yeast.
1996 Jul.
Abstract
A DNA ligase-encoding gene (Ca CDC9) was cloned from Candida albicans by complementation of an ime-1 mutation in Saccharomyces cerevisiae. In this system, IME1 function was assayed using a S. cerevisiae strain with a ime2-promoter-lacZ gene fusion such that following transformation with a C. albicans genomic library, the presence of positive clones was indicated upon the addition of X-gal to sporulation media. Transforming fragments were subcloned in pGEM7 and sequenced. Sequence homology with several ATP-dependent DNA ligases from viruses, fission yeast, human, baker yeast and bacteria was observed.
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