[Uptake of gamma-aminobutyric acid by 3H-glial cells and synaptosomes of rat cerebral cortex under the influence of psychotropic substances]

Abstract

Chlorpromazine was shown to inhibit non-competitively the 3H-GABA uptake both by the glial cells and synaptosomes; synaptosomal uptake was more sensitive to the inhibitor. Only the low-affinity GABA uptake in the glial cells was competitively inhibited by beta-alanine. On the whole, there was a correlation between the inhibition of GABA uptake by psychotropic drugs in the glial cells and in the synaptosomes. It is assumed that there existed two different systems of GABA uptake (of high and low affinity) in the nerve endings and glial cells.