[Effect of morphine and azidomorphine on the neuronal activity of the cerebral cortex]

Abstract

Acute experiments were conducted on unanesthetized curare-treated cats and rats. Analgetic doses of morphine and azidomorphine proved to depress the spontaneous and bradykinin-induced neuronal activity in the sensory-motor zone of the cerebral cortex. The inhibiting effect of the drugs was eliminated by nalorphine. It is supposed that the depressive action of morphine and azidomorphine may be connected with their direct influence on the cerebral cortex.