doi: 10.1093/infdis/174.4.888.
Role of extended culture time on synergy of fluconazole and human monocyte-derived macrophages in clearing Candida albicans
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- PMID: 8843238
- DOI: 10.1093/infdis/174.4.888
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Role of extended culture time on synergy of fluconazole and human monocyte-derived macrophages in clearing Candida albicans
J Infect Dis.
1996 Oct.
Abstract
Possible enhanced candidacidal synergy of fluconazole and human monocyte-derived macrophages by extended culture time was studied. Synergistic candidacidal activity increased from 1 day to 3 days and was maximal at 6 days. Enhanced synergistic candidacidal activity at 144 h was observed over a 10-fold challenge dose range. Enhanced synergy with culture time was seen with fluconazole-susceptible and -resistant isolates of Candida albicans. These findings emphasize the importance of dosage and an adequate period of therapy.
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