Comparative Study
doi: 10.1128/AAC.40.8.1948.
In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species
Affiliations
- PMID: 8843312
- PMCID: PMC163448
- DOI: 10.1128/AAC.40.8.1948
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Comparative Study
In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species
Antimicrob Agents Chemother.
1996 Aug.
Abstract
A new triazole derivative (voriconazole or UK-109,496) and fluconazole were tested against 249 isolates of Candida spp. representing six species. Voriconazole was 10 to 100 times more potent than fluconazole. Strains with decreased susceptibility to fluconazole were inhibited by relatively low concentrations of voriconazole.
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