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Comparative Study
. 1996 Aug;40(8):1948-9.
doi: 10.1128/AAC.40.8.1948.

In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species

A L Barry  1 , S D Brown
Affiliations
Comparative Study

In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species

A L Barry et al. Antimicrob Agents Chemother. 1996 Aug.

Abstract

A new triazole derivative (voriconazole or UK-109,496) and fluconazole were tested against 249 isolates of Candida spp. representing six species. Voriconazole was 10 to 100 times more potent than fluconazole. Strains with decreased susceptibility to fluconazole were inhibited by relatively low concentrations of voriconazole.

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