doi: 10.1016/0730-725x(96)00048-3.
Brain metabolite changes in alcoholism: an in vivo proton magnetic resonance spectroscopy (MRS) study
Affiliations
- PMID: 8843367
- DOI: 10.1016/0730-725x(96)00048-3
Item in Clipboard
Brain metabolite changes in alcoholism: an in vivo proton magnetic resonance spectroscopy (MRS) study
Magn Reson Imaging.
1996.
Abstract
Image-guided, single voxel, localized proton magnetic resonance (MR) spectroscopy was performed to assess the brain metabolite changes in 10 (n = 10) alcoholic patients in the frontal lobe, cerebellum, and thalamus regions. The spectra obtained were characterized by a reduced N-acetyl-aspartate (NAA) to choline (Cho) (p < .01) and NAA to total creatine (Cr + PCr) (p < .01) ratios relative to age-matched (n = 27) controls. These decreased ratios correspond to depleted concentration of the metabolite levels such as NAA and Cho. Reduction of NAA is consistent with the neuronal loss while reduction in Cho suggests significant changes in the membrane lipids of alcoholics.
Similar articles
-
Localized proton magnetic resonance spectroscopy of the cerebellum in detoxifying alcoholics.Alcohol Clin Exp Res. 1999 Jan;23(1):158-63. Alcohol Clin Exp Res. 1999. PMID: 10029218
-
Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy.Alcohol Clin Exp Res. 2002 Sep;26(9):1368-80. doi: 10.1097/01.ALC.0000029598.07833.2D. Alcohol Clin Exp Res. 2002. PMID: 12351932
-
Multivoxel proton magnetic resonance spectroscopy in heat stroke.Clin Radiol. 2015 Jan;70(1):37-41. doi: 10.1016/j.crad.2014.09.004. Epub 2014 Nov 4. Clin Radiol. 2015. PMID: 25443777
-
In vivo quantitation of metabolite concentrations in the brain by means of proton MRS.NMR Biomed. 1995 Jun;8(4):139-48. doi: 10.1002/nbm.1940080402. NMR Biomed. 1995. PMID: 8771088 Review.
-
Magnetic resonance imaging of the living brain: evidence for brain degeneration among alcoholics and recovery with abstinence.Alcohol Res Health. 2008;31(4):362-76. Alcohol Res Health. 2008. PMID: 23584010 Free PMC article. Review.
Cited by
-
Brain metabolite alterations related to alcohol use: a meta-analysis of proton magnetic resonance spectroscopy studies.Mol Psychiatry. 2022 Aug;27(8):3223-3236. doi: 10.1038/s41380-022-01594-8. Epub 2022 May 4. Mol Psychiatry. 2022. PMID: 35508628 Free PMC article.
-
Clinical and pathological features of alcohol-related brain damage.Nat Rev Neurol. 2011 May;7(5):284-94. doi: 10.1038/nrneurol.2011.42. Epub 2011 Apr 12. Nat Rev Neurol. 2011. PMID: 21487421 Free PMC article. Review.
-
Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study.Neuropsychopharmacology. 2018 Aug;43(9):1876-1883. doi: 10.1038/s41386-018-0089-6. Epub 2018 May 9. Neuropsychopharmacology. 2018. PMID: 29795404 Free PMC article.
-
Perturbation of the glutamate-glutamine system in alcohol dependence and remission.Neuropsychopharmacology. 2011 Jun;36(7):1359-65. doi: 10.1038/npp.2011.20. Epub 2011 Mar 9. Neuropsychopharmacology. 2011. PMID: 21389979 Free PMC article.
-
Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolites.Alcohol Clin Exp Res. 2004 Apr;28(4):650-61. doi: 10.1097/01.alc.0000121805.12350.ca. Alcohol Clin Exp Res. 2004. PMID: 15100618 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
