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. 1977 Sep;37(9):3455-7.

Lack of cross-resistance between certain platinum coordination compounds in mouse leukemia

J H Burchenal, K Kalaher, T O'Toole, J Chisholm
  • PMID: 884687

Lack of cross-resistance between certain platinum coordination compounds in mouse leukemia

J H Burchenal et al. Cancer Res. 1977 Sep.

Abstract

Two congeners of cis-platinum diamminodichloride, 1,2-diamminocyclohexylplatinum malonate (NSC 224964) and 1,2-cyclohexyldiamminoplatinum sulfate (NSC 250427), show approximately equal inhibitory activity in vitro against leukemia L1210 and a line of L1210 (L1210/PDD) that has developed resistance to cis-platinum diamminodichloride. These compounds are also active against L1210/PDD in vivo. These observations suggest that they be tried clinically in patients whose disease has become resistant to cis-platinum diamminodichloride.

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