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. 1995 Dec:76 ( Pt 12):3201-4.
doi: 10.1099/0022-1317-76-12-3201.

Detection of measles virus nucleoprotein mRNA in autopsied brain tissues

Y Katayama  1 , H Hotta, A Nishimura, Y Tatsuno, M Homma
Affiliations

Detection of measles virus nucleoprotein mRNA in autopsied brain tissues

Y Katayama et al. J Gen Virol. 1995 Dec.

Abstract

By means of RT-PCR, a portion of measles virus (MV) mRNA encoding nucleoprotein (NP) could be detected in 11 (18%) of 61 brain tissue samples obtained from administrative autopsy cases, who apparently had not suffered from subacute sclerosing panencephalitis (SSPE)-like central nervous system disorders. Most of the brain-derived NP sequences showed significant asynonymous nucleotide substitutions when compared with wild-type MV isolates and SSPE virus. Our present results suggest that MV commonly persists in the human brain without causing apparent clinical symptoms, probably due to decreased virus replication.

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