Decrypting class I MHC-bound peptides with peptide libraries

Abstract

Multiple peptides have been used as molecular tools to probe the selective, yet degenerative, recognition of peptides by class I major histocompatibility complex (MHC) molecules and T-cell receptors. The additive contributions from individual amino acids that have been identified experimentally can often be used to predict the binding of any peptide to class I MHC molecules, although other contributing factors will often result in this being an oversimplification.