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Comparative Study
. 1996 Apr;40(4):1020-3.
doi: 10.1128/AAC.40.4.1020.

Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles

T Deguchi  1 , M Yasuda, M Nakano, S Ozeki, T Ezaki, I Saito, Y Kawada
Affiliations
Comparative Study

Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles

T Deguchi et al. Antimicrob Agents Chemother. 1996 Apr.

Abstract

Fifty-five clinical strains of Neisseria gonorrhoeae were examined for mutations in the gyrA and parC genes and for antimicrobial susceptibility profiles. The MICs of quinolones for 31 strains with alterations in GyrA were significantly higher than the MICs for 24 strains without such alterations. Eleven strains with alterations in both GyrA and ParC were significantly more resistant to fluoroquinolones than those with alterations in GyrA alone. The MICs of cephalosporins for these strains were also significantly higher than those for other strains.

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References

    1. Antimicrob Agents Chemother. 1990 Jun;34(6):1271-2 - PubMed
    1. Antimicrob Agents Chemother. 1991 Apr;35(4):622-6 - PubMed
    1. MMWR CDC Surveill Summ. 1993 Aug 13;42(3):29-39 - PubMed
    1. Sex Transm Dis. 1993 Nov-Dec;20(6):329-33 - PubMed
    1. Antimicrob Agents Chemother. 1995 Feb;39(2):561-3 - PubMed

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