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Comparative Study
. 1996 Apr;40(4):1050-2.
doi: 10.1128/AAC.40.4.1050.

Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance

O Lomovskaya  1 , F Kawai, A Matin
Affiliations
Comparative Study

Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance

O Lomovskaya et al. Antimicrob Agents Chemother. 1996 Apr.

Abstract

The mcb operon (which is responsible for microcin B17 production) and the emr operon (which encodes a multidrug resistance pump) share a common negative regulator, EmrR. Nevertheless, compounds that induce the emr operon repress the mcb operon. The pump dedicated to microcin B17 extrusion can also protect the calls against sparfloxacin and other toxic compounds.

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