Review
doi: 10.1126/science.274.5287.546.
Life with 6000 genes
Affiliations
- PMID: 8849441
- DOI: 10.1126/science.274.5287.546
Item in Clipboard
Review
Life with 6000 genes
Science.
.
Abstract
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.
Comment in
-
Funding sequencing efforts.Science. 1997 Feb 21;275(5303):1051-2. doi: 10.1126/science.275.5303.1049f. Science. 1997. PMID: 9054002 No abstract available.
Similar articles
-
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.Science. 1994 Sep 30;265(5181):2077-82. doi: 10.1126/science.8091229. Science. 1994. PMID: 8091229
-
Analysis of an 11.7 kb DNA fragment of chromosome XI reveals a new tRNA gene and four new open reading frames including a leucine zipper protein and a homologue to the yeast mitochondrial regulator ABF2.Yeast. 1994 Jan;10(1):125-30. doi: 10.1002/yea.320100112. Yeast. 1994. PMID: 8203146
-
The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes.Yeast. 1994 Sep;10(9):1235-49. doi: 10.1002/yea.320100912. Yeast. 1994. PMID: 7754713
-
A genomic perspective on protein families.Science. 1997 Oct 24;278(5338):631-7. doi: 10.1126/science.278.5338.631. Science. 1997. PMID: 9381173 Review.
-
The yeast genome: on the road to the Golden Age.Curr Opin Genet Dev. 2000 Dec;10(6):617-23. doi: 10.1016/s0959-437x(00)00145-3. Curr Opin Genet Dev. 2000. PMID: 11088011 Review.
Cited by
-
Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions.Front Physiol. 2021 May 19;12:675708. doi: 10.3389/fphys.2021.675708. eCollection 2021. Front Physiol. 2021. PMID: 34093236 Free PMC article. Review.
-
The SEQUEST family tree.J Am Soc Mass Spectrom. 2015 Nov;26(11):1814-9. doi: 10.1007/s13361-015-1201-3. Epub 2015 Jun 30. J Am Soc Mass Spectrom. 2015. PMID: 26122518 Free PMC article.
-
Transparent mediation-based access to multiple yeast data sources using an ontology driven interface.BMC Bioinformatics. 2012 Jan 25;13 Suppl 1(Suppl 1):S7. doi: 10.1186/1471-2105-13-S1-S7. BMC Bioinformatics. 2012. PMID: 22372975 Free PMC article.
-
JLOH: Inferring loss of heterozygosity blocks from sequencing data.Comput Struct Biotechnol J. 2023 Nov 7;21:5738-5750. doi: 10.1016/j.csbj.2023.11.003. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 38074465 Free PMC article.
-
Next Generation Winemakers: Genetic Engineering in Saccharomyces cerevisiae for Trendy Challenges.Bioengineering (Basel). 2020 Oct 14;7(4):128. doi: 10.3390/bioengineering7040128. Bioengineering (Basel). 2020. PMID: 33066502 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
