Distinctive developmental origins and specificities of the CD5+ B-cell subset

Abstract

In this review we present our recent work defining the pathway of B-cell development in the adult bone marrow of the mouse. We next present similarities and contrasts between fetal and adult B lymphopoiesis. Finally, considering the striking biases in specificity and V-gene usage between the progeny of fetal B lymphopoiesis, CD5+ B cells, and the bulk of adult-derived CD5- B cells, we suggest a model for developmentally distinct generation of this subset.