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. 1996 Mar;40(3):792-4.
doi: 10.1128/AAC.40.3.792.

Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo

P Hafkemeyer  1 , A Keppler-Hafkemeyer, M A al Haya, M von Janta-Lipinski, E Matthes, C Lehmann, W B Offensperger, S Offensperger, W Gerok, H E Blum
Affiliations

Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo

P Hafkemeyer et al. Antimicrob Agents Chemother. 1996 Mar.

Abstract

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.

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