Comparative Study
doi: 10.1128/AAC.40.3.799.
In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis
Affiliations
- PMID: 8851617
- PMCID: PMC163204
- DOI: 10.1128/AAC.40.3.799
Item in Clipboard
Comparative Study
In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis
Antimicrob Agents Chemother.
1996 Mar.
Abstract
The new oxazolidinone antimicrobial agents U100592 and U100766 demonstrated good in vitro inhibitory activity against clinical strains of Staphylococcus aureus and Staphylococcus epidermidis regardless of methicillin susceptibility. Both agents appeared bacteriostatic by time-kill analysis. Stable resistance to low multiples of the MIC of either drug could be produced only in methicillin-resistant S. aureus.
Similar articles
-
Oxazolidinones: a review.Drugs. 2000 Jan;59(1):7-16. doi: 10.2165/00003495-200059010-00002. Drugs. 2000. PMID: 10718097 Review.
-
In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis.Antimicrob Agents Chemother. 1996 Oct;40(10):2428-30. doi: 10.1128/AAC.40.10.2428. Antimicrob Agents Chemother. 1996. PMID: 8891159 Free PMC article.
-
Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium.Antimicrob Agents Chemother. 1998 Mar;42(3):721-4. doi: 10.1128/AAC.42.3.721. Antimicrob Agents Chemother. 1998. PMID: 9517963 Free PMC article.
-
Comparative in vitro activity of linezolid and five other antimicrobials against nosocomial isolates of methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium.J Chemother. 2003 Oct;15(5):442-8. doi: 10.1179/joc.2003.15.5.442. J Chemother. 2003. PMID: 14603881
-
Antibiotic resistance in Staphylococcus aureus and its relevance in therapy.Expert Opin Pharmacother. 2005 Oct;6(13):2257-69. doi: 10.1517/14656566.6.13.2257. Expert Opin Pharmacother. 2005. PMID: 16218886 Review.
Cited by
-
Oxazolidinones: a review.Drugs. 2000 Jan;59(1):7-16. doi: 10.2165/00003495-200059010-00002. Drugs. 2000. PMID: 10718097 Review.
-
A critical review of oxazolidinones: an alternative or replacement for glycopeptides and streptogramins?Can J Infect Dis. 2001 Nov;12(6):379-90. doi: 10.1155/2001/260651. Can J Infect Dis. 2001. PMID: 18159365 Free PMC article.
-
The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria.Antimicrob Agents Chemother. 1998 Dec;42(12):3251-5. doi: 10.1128/AAC.42.12.3251. Antimicrob Agents Chemother. 1998. PMID: 9835522 Free PMC article.
-
In vivo efficacy of continuous infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model.Antimicrob Agents Chemother. 2002 Dec;46(12):3706-11. doi: 10.1128/AAC.46.12.3706-3711.2002. Antimicrob Agents Chemother. 2002. PMID: 12435665 Free PMC article.
-
Clinical outcome with oral linezolid and rifampin following recurrent methicillin-resistant Staphylococcus aureus bacteremia despite prolonged vancomycin treatment.Can J Infect Dis. 2004 Mar;15(2):97-100. doi: 10.1155/2004/768765. Can J Infect Dis. 2004. PMID: 18159483 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
