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Comparative Study
. 1996 Mar;40(3):809-11.
doi: 10.1128/AAC.40.3.809.

Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis

D Vermot  1 , J M Entenza, J Vouillamoz, M P Glauser, P Moreillon
Affiliations
Comparative Study

Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis

D Vermot et al. Antimicrob Agents Chemother. 1996 Mar.

Abstract

Clarithromycin is compared with clindamycin for single-dose prophylaxis of streptococcal endocarditis in rats. Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against small amounts of inocula. Clarithromycin may be considered for endocarditis chemoprophylaxis in human.

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