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Comparative Study
. 1996 Mar;14(1):1-14.

Synthesis and bronchodilatory activity of four new derivatives of deoxyvasicine

B Ojo  1 , L A Findsen, N Igarashi, B Kong, B K Chowdhury
Affiliations
  • PMID: 8854041
Comparative Study

Synthesis and bronchodilatory activity of four new derivatives of deoxyvasicine

B Ojo et al. Drug Des Discov. 1996 Mar.

Abstract

As part of a continuing effort aimed at the development of efficacious antihistaminic and bronchodilator agents for the treatment of asthma and related respiratory diseases, a series of novel trisubstituted deoxyvasicine derivatives was designed and synthesized. Bronchodilatory activity of pure samples of ligands 17a-d, and DL-8-chlorovasicine hydrochloride is investigated and compared with isoprenaline and aminophylline. These studies confirm the activity of ligands 17a-d and the potentiating effect of 17c on aminophylline.

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