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. 1996 Oct 1;93(20):10703-6.
doi: 10.1073/pnas.93.20.10703.

Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module

K W Plaxco  1 , C Spitzfaden, I D Campbell, C M Dobson
Affiliations

Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module

K W Plaxco et al. Proc Natl Acad Sci U S A. .

Abstract

Fibronectin type III modules contain approximately 90 residues and are an extremely common building block of animal proteins. Despite containing a complex all-beta-sheet topology and eight prolines, the refolding of the 10th type III module of human fibronectin has been found to be very rapid, with native core packing, amide hydrogen bonding, and backbone conformation all recovered within 1 s at 5 degrees C. These observations indicate that this domain can overcome many structural characteristics often thought to slow the folding process.

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References

    1. J Mol Biol. 1978 Nov 5;125(3):401-6 - PubMed
    1. Nat Struct Biol. 1995 Aug;2(8):663-73 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6157-61 - PubMed
    1. Eur J Biochem. 1981;114(1):105-9 - PubMed
    1. Eur J Biochem. 1981;114(1):111-7 - PubMed

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