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. 1977 Jun 30;37(2):131-9.
doi: 10.1007/BF00393575.

Localization of HLA on the short arm of chromosome 6

M H Breuning, E M van den Berg-Loonen, L F Bernini, J B Bijlsma, E van Loghem, P Meera Khan, L E Nijenhuis

Localization of HLA on the short arm of chromosome 6

M H Breuning et al. Hum Genet. .

Abstract

A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21; p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtained at a recombination value of 0.05 for a linkage between HLA and the breakpoint, indicating that the chromosomal region, carrying the HLA genes, is situated near the breakpoint in band 6p21 close to the transition to 6p22.

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