Regional chromosomal localization of the human gene for galactose-1-phosphate uridyltransferase
- PMID: 885547
- DOI: 10.1007/BF00393609
Regional chromosomal localization of the human gene for galactose-1-phosphate uridyltransferase
Abstract
In the progeny of somatic cell hybrids formed by fusion of human lymphocytes and Chinese hamster mutant cells, a single human chromosome A2 was selectively retained when grown in appropriate medium. Spontaneous breakage of this chromosome in different hybrid subclones led to the assignment of the gene for galactose-1-phosphate uridyltransferase to the centromeric region of this chromosome (2q11 leads to 2q14). This gene is shown to be syntenic to the previously mapped genes for acid phosphatase 1 and malate dehydrogenase 1.
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