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Clinical Trial
. 1996 Jul;126(2):179-81.
doi: 10.1007/BF02246354.

Low dose melatonin improves sleep in healthy middle-aged subjects

M E Attenburrow  1 , P J Cowen, A L Sharpley
Affiliations
Clinical Trial

Low dose melatonin improves sleep in healthy middle-aged subjects

M E Attenburrow et al. Psychopharmacology (Berl). 1996 Jul.

Abstract

We studied the effects of single evening doses of melatonin (0.3 mg and 1.0 mg orally) on polysomnographically measured sleep in 15 healthy middle-aged volunteers, using a placebo-controlled, double-blind, cross-over design. Compared to placebo, the 1.0 mg dose of melatonin significantly increased Actual Sleep Time, Sleep Efficiency, non-REM Sleep and REM Sleep Latency. These data are consistent with the hypothesis that low dose melatonin has hypnotic effects in humans. It is possible that administered melatonin may have a role to play in the treatment of sleep disorders.

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