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Review
. 1996 Aug;4(8):307-12.
doi: 10.1016/0966-842x(96)10048-2.

DNA immunization

D E Hassett  1 , J L Whitton
Affiliations
Review

DNA immunization

D E Hassett et al. Trends Microbiol. 1996 Aug.

Abstract

Inoculation with plasmid DNA vectors encoding immunogenic proteins induces both humoral and cell-mediated immune responses, which often provide protective immunity. Although many questions regarding the mechanism, efficacy and safety of DNA immunization remain to be addressed, this approach may offer a safer and more cost-effective alternative to conventional vaccines.

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