doi: 10.7164/antibiotics.30.474.
Microbial transformation of antibiotics. Clindamycin ribonucleotides
- PMID: 885808
- DOI: 10.7164/antibiotics.30.474
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Microbial transformation of antibiotics. Clindamycin ribonucleotides
J Antibiot (Tokyo).
1977 Jun.
Free article
Abstract
Addition of clindamycin to whole-cell cultures of Streptomyces coelicolor Müller resulted in the loss of in vitro activity against organisms sensitive to clindamycin. Incubation of such culture filtrates with crude alkaline phosphatase generated a biologically active material identified as clindamycin. Fermentation broths containing inactivated clindamycin yielded clindamycin 3-ribonucleotides and clindamycin 3-phosphate the structure of which was established by physicochemical and enzymatic means. Attempts to transform clindamycin to clindamycin 3-ribonucleotides by lysates or partially purified enzyme preparations from S. coelicolor have failed.
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