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. 1996 Oct;122(10):1112-6.
doi: 10.1001/archotol.1996.01890220078013.

Effect of topical diphenhydramine on the laryngeal chemoreflex

H C Boyer  1 , D H Downs, G S Goding Jr, K J Pernell
Affiliations

Effect of topical diphenhydramine on the laryngeal chemoreflex

H C Boyer et al. Arch Otolaryngol Head Neck Surg. 1996 Oct.

Abstract

Objective: To study diphenhydramine nebulization as a clinically applicable method for blunting laryngeal chemoreflex (LCR)-associated apnea.

Interventions: Fourteen piglets aged 15 to 18 days were studied. In 7 piglets, diphenhydramine hydrochloride (5.0 mg/kg) was nebulized onto the laryngeal mucosa after a baseline response was obtained.

Results: After a 10-minute waiting period, the mean +/- SD LCR-induced apnea duration decreased from 29 +/- 13 seconds in the control animals to 15 +/- 5 seconds in the treated group (P = .02, 1-factor analysis of variance). After 1 hour, no treatment effect was seen.

Conclusions: Nebulization of diphenhydramine can effectively reduce LCR-induced apnea for a short time. Nebulization of longer-acting agents may provide an effective prophylaxis of LCR-induced apnea.

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