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Clinical Trial
. 1996;246(5):249-55.
doi: 10.1007/BF02190276.

Neuropsychological impairment in first-episode and chronic schizophrenic patients

M Albus  1 , W Hubmann, C Ehrenberg, U Forcht, F Mohr, N Sobizack, C Wahlheim, S Hecht
Affiliations
Clinical Trial

Neuropsychological impairment in first-episode and chronic schizophrenic patients

M Albus et al. Eur Arch Psychiatry Clin Neurosci. 1996.

Abstract

Patients with first-episode (FE) schizophrenia (n = 40), with chronic schizophrenia (n = 40) and healthy controls (n = 40) matched for age, gender, education and parental socioeconomic status were administered a battery of standardized neuropsychological (NP) tests. Both patient groups showed generalized impairment relative to controls and the most pronounced deficits in visual-motor processing and attention (VSM). Compared with FE patients, chronic schizophrenics performed worse in VSM and abstraction/flexibility. Our findings suggest that NP deficits are fundamental manifestations of the illness, and that mainly frontally based dysfunctions are more prominent in chronic, kraepelinian patients.

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