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. 1996 Nov 1;274(5288):787-9.
doi: 10.1126/science.274.5288.787.

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

D J Van Antwerp  1 , S J Martin, T Kafri, D R Green, I M Verma
Affiliations

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

D J Van Antwerp et al. Science. .

Abstract

Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IkappaBalpha (IkappaBalphaM). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappaB activation suppresses the signals for cell death.

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