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. 1996 Sep;59(9):896-9.
doi: 10.1021/np960450y.

(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties

T C McMorris  1 , M J Kelner, W Wang, J Yu, L A Estes, R Taetle
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(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties

T C McMorris et al. J Nat Prod. 1996 Sep.

Abstract

Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The primary allylic hydroxyl thus formed can undergo very facile replacement by a variety of nucleophiles. (Hydroxymethyl)acylfulvene (MGI.114) was more toxic than a precursor, acylfulvene, but less toxic than the parent compound illudin S to HL 60 cells.

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